The shifting landscapes of health and health philanthropy have created profound needs and opportunities that Non-tradtiional actors (NTAs) are particularly well-suited to address. Due to the significant policy changes and demographic inevitabilities of the coming decades, the U.S. health system is poised to add millions of new users over the next 10 years, creating a deep need among service providers to build capacity, refine best practices, and scale proven programs to serve more people. Health philanthropy has been adapting to meet these needs, but even the significant resources of THFs are not adequate to address the anticipated growth in the health care needs of this country. NTAs in health philanthropy include a wide variety of organizations and institutions, including corporations, CDFIs, venture philanthropists, start-ups, and young donors. Many corporations have their own in-house charitable giving programs. Although much of their support may be in the form of grants, corporations often have different priorities and preferred approaches than traditional grantmaking foundations. Established by the U.S. Treasury Department in 1994, community development financial institutions (CDFIs) are financial institutions that provide credit and financial services to underserved markets and populations. In the United States, the Treasury Department certifies CDFIs and provides them with funds through a variety of financial programs. Venture philanthropists seek to make long-term, high-engagement investments in community-based organizations, in much the same way that venture capitalists provide valuable seed funding to for-profit entities. A variety of high-tech start-ups have emerged to explore and expand new ways to identify worthy philanthropic investments and direct resources accordingly. On an individual level, many younger next-generation donors possess different priorities and risk tolerances than earlier generations of individual donors.